At Kisbee Therapeutics, we are engineering recombinant lipoproteins to target the core biological systems underlying neurodegenerative diseases. Our work represents a novel approach to address the problem of lipid dysregulation observed across many CNS (central nervous system) diseases.
Genetically Validated Approach to Restore Lipid Homeostasis
A growing body of scientific evidence has linked dysfunctional lipid biology to the onset and severity of neurodegenerative disease.
Human genetics has shown that ineffective lipoprotein function as well as mutations in lipid transport genes are central drivers of neurodegeneration. Failure to properly regulate lipid transport between neurons, astrocytes, and microglia leads to excitotoxicity, impaired debris clearance, protein accumulation, inflammation, and reduced lysosomal function, all hallmarks of many neurodegenerative diseases.
By use of our highly optimized, engineered lipoproteins, also known as Kisbee Discs, we are able to intervene and restore lipid homeostasis – gathering and transporting lipids to where they are needed.
Kisbee is focused on advancing programs where we can use biomarkers to connect relevant biology in genetically defined patient populations to improve our ability to demonstrate efficacy and to further characterize the potential therapeutic benefit of our approach. Alzheimer’s disease, along with several other rare, chronic, and acute neurodegenerative conditions, are in focus for initial therapeutic development efforts.
At Kisbee, we have a shared mission with the patient communities we serve to develop new and impactful therapies. We know this mission is best achieved by working together and by having the patient’s perspective of the diseases we are researching.
To listen, really listen, to the patient communities we serve to understand unmet needs and your lived experience
To be transparent about our work
To actively partner with advocacy organizations globally throughout the drug development process
If you have questions or would like to connect with a member of our patient advocacy team, please contact us at patients@kisbeetx.com
Meet the experts behind our vision
Join us in creating a new class of therapeutics for neurodegenerative disease
Kisbee is developing lipid-based therapeutics for neurodegenerative diseases and CNS injuries by bringing together passionate scientists and drug developers. Our diverse experiences and perspectives enable us to support and challenge one another, fostering care, respect, and collaboration. New ideas and innovation fuel us. Science and data guide us. Novel challenges and opportunities bring out our best. We are passionate and driven, and we aspire to overcome obstacles with creativity and careful risk-taking, striving to make a difference for patients.
We show up, we speak with honesty and deliver what we promise. We are confident in one another’s capabilities, display integrity in all things, and assume best intent knowing that we each keep everyone’s best interests at heart
We embrace our different backgrounds, experiences, and viewpoints to strengthen our fabric and enhance our outcomes. Our interactions are driven by universal compassion, so we act with humility and a willingness to understand everyone’s perspective
We leverage our relentless passion for our patients, our business, and our science by creatively looking at things through a different lens, humbly considering alternatives, and remaining eager to learn
We share what we should, when we should. We trust each other to demonstrate sound discernment and to honor the best interests of the individuals when sharing
We exercise mature judgment so we’re entrusted to think, experiment, and discover for ourselves. We’re not afraid to take informed risks, embrace challenges, and push boundaries in order to grow Kisbee and support patients
We are actively hiring across a range of roles in R&D, HR, Finance, and Operations. To inquire about open roles, please email recruiting@kisbeetx.com
Matt joined Kisbee as Chief Scientific Officer after serving as Senior Vice President and Division Head for Gene Therapy Research and Technical Operations at Astellas Gene Therapies. In this role, he managed a global team of approximately 350 individuals spread across North Carolina, California and Japan, responsible for leading the Astellas' pre-clinical gene therapy portfolio and all gene therapy manufacturing activities from project initiation through commercialization.
Mathew received a PhD in human genetics from the Johns Hopkins School of Medicine and conducted a post-doctoral fellowship at the Genomics Institute of the Novartis Research Foundation, publishing the first haplotype map of mouse inbred strains. After establishing his own laboratory at the Scripps Research Institute in Florida and acting as the director of its Genetics and Genomics Core Facility, Mathew joined Pfizer Global Research and Development, eventually serving as Director of Medical Genetics for Pfizer's Rare Disease Research Unit.
More recently, Mathew served as the Chief Science Officer for Autism Speaks, the world's largest advocacy and research organization for autism. As part of this role, he led MSSNG, a collaboration between Autism Speaks, Google and the Hospital for Sick Children, to make available in an open-access database more than 10,000 whole genome sequences from families with autism. Prior to arriving at Astellas Gene Therapies, he served as the Head of Rare Disease directing early development and research activities for rare neuromuscular, neurodevelopmental, ophthalmological, neurodegenerative, and hematopoietic diseases including Angelman syndrome, spinal muscular atrophy, choroideremia, spinocerebellar ataxia, and Huntington disease. He has also founded the RDH12 Fund for Sight, a non-profit organization devoted to the development of a gene therapy for a genetic form of Leber Congenital Amaurosis, a congenital blinding disorder; is a board member of Odylia Therapeutics, a non-profit enterprise focused on developing gene therapies for ultra-rare diseases; and holds an adjunct faculty appointment with the University of North Carolina.
